We recently conducted a clinical trial on our frontline product to combat Candida overgrowth and other gut issues: CanXida Remove (Formula RMV). This triple-blinded study followed the responses of 30 female participants to CanXida Remove (Formula RMV) over 12 weeks. It was the first such study that CanXida has performed, and it revealed essential insights into this product that will help guide future research. The research showed that CanXida Remove (Formula RMV) significantly improved how participants rated their gastrointestinal and mental health after taking the product. Most participants who took CanXida Remove (Formula RMV) expressed a desire to keep taking it and would recommend it to others. While this trial represents just the first step in the clinical testing of CanXida products, the results reflect what our clients have told us for years: CanXida Remove (Formula RMV) positively impacts their gastrointestinal and mental health.

1. Introduction

1. Clinical Testing for Supplements

Companies are not required to perform clinical trials on their supplements before marketing them to consumers¹. This means that while many companies promote their products with bold claims, these claims are rarely backed up by robust scientific data. While regulators like the FDA have recently become more strict with what companies can and cannot say regarding their products², a disconnect remains between what companies claim and what there is actual evidence for. However, it’s important to note that just because a company hasn’t performed a clinical trial doesn’t mean their product doesn’t work. It simply means they have not proven it works using robust scientific methodology.

1.1.1. The Challenges of Clinical Testing – The Extra Mile

Clinical trials are very challenging to perform. They are expensive, technically and logistically demanding, and prone to variations and pitfalls like any scientific experiment³. Today, pharmaceutical companies spend up to one billion dollars to get one drug through clinical trials, and the whole process takes about a decade. While clinical trials for supplements don’t take as long or require so much money, they are an inherently expensive process with no guarantee of success. Clinical trials require the recruitment of individuals at widespread geographic locations, and each participant must stick to the treatment plan for the trial to be successful.

1.2. Our Commitment to Our Clients

At CanXida, we base all of our claims about our ingredients on scientific evidence from the existing pool of literature. However, we want to go further and show that our supplements work by performing scientifically robust clinical trials. Many companies aren’t interested in testing their products either because of the expense and difficulties involved in clinical testing or because they are afraid of getting negative results. At CanXida, we believe our clients deserve to know that what we are selling them works. Over the years, we’ve gained a full appreciation for our client base’s intelligence and understand the need to back up our client’s success stories with scientific data.

1.3. CanXida Remove (Formula RMV)

CanXida Remove (Formula RMV) is our frontline supplement for dealing with Candida overgrowth and helping to resolve the digestive issues it can cause. The ingredients in CanXida Remove (Formula) are all backed up by scientific studies and help to tackle fungal, bacterial, and parasitic issues.

1.3.1. Existing Literature

CanXida Remove (Formula RMV) Ingredients:

The following briefly summarizes the scientific support for CanXida Remove (Formula RMV) ingredients. Our dedicated white paper provides a more detailed description of these ingredients⁴.

• Grapefruit seed extract (GSE): Shown to reduce the amount of Candida albicans in an animal model of vaginal candidiasis and have broad antibacterial effects^5,6.
• Berberine concentrate HCl: Possesses antifungal and bacteria properties and has been shown to make antifungal treatments more effective^7,8.
• Clove: Contains the active ingredient eugenol that kills Candida and other fungal species⁹.
• Garlic: Contains the active ingredient allicin that has anti-fungal (including Candida¹⁰) and antibacterial properties¹¹.
• Caprylic acid: A medium-chain fatty acid has been shown to improve symptoms of oral candidiasis (Candida albicans) in an animal model and has antimicrobial properties^12,13.
• Undecylenic acid: Shown to reduce Candida albicans biofilm formation and prevent it from entering its more invasive morphology (shape)¹⁴.
• Betaine HCl: Reduces the pH of the stomach (makes it more acidic), which is important for limiting Candida growth^15,16.
• Black walnut hull extract: Contains the active ingredient juglone, which has been shown to have antifungal, antibacterial, and antiparasitic properties^17–19.
• Pau D’Arco: Has been shown to be effective against several Candida species²⁰.
• Neem: Has antimicrobial activity, including against Candida^21,22.
• Biotin: Biotin is an essential cofactor for carboxylase enzymes and is integral to metabolic processes like gluconeogenesis and amino acid metabolism²³.
• Oregano oil: Has been shown to inhibit the growth of Candida albicans and helps to prevent the formation of Candida biofilms^24,25.

There is evidence that CanXida Remove (Formula RMV) ingredients have synergistic effects against Candida when combined. For instance, a combination of neem and clove extracts has shown added benefits against fungal species, including Candida²⁶.

1.3.2. Challenges of Clinical Testing for CanXida Remove (Formula RMV)

Designing a clinical trial for CanXida Remove (Formula RMV) presented several challenges. Our client testimonials collectively show that CanXida Remove (Formula RMV) has helped people address various health issues beyond digestive problems. This is why we refer to it as a natural broad-spectrum solution. Furthermore, CanXida Remove (Formula RMV) has relieved symptoms for individuals across different age groups, geographic locations, and genetic backgrounds. Some clients have experienced immediate relief, while others have only benefited after months or even years of continuous use. We also know that the effective dosage varies between individuals. Together, these differences made it challenging to define precise parameters for our trial including:

• What symptoms should we focus on when recruiting participants?
• What age groups should they fit into?
• How long should the trial run for?
• What should the dosage be?

With this appreciation for the variety of use cases and responses to CanXida Remove (Formula RMV), we decided to take a broad approach and examine the supplement’s general effects without delving into detail on a specific area. This approach aimed to lay the groundwork for more focused clinical trials in the near future.

The testimonials and feedback generously provided by our clients were indispensable when designing this trial. The testimonials provided insights into use cases, recovery timelines, and adverse responses to CanXida Remove (Formula RMV), which helped us define several trial parameters.

2. Methodology

2.1. Trial Overview

In this study, we looked at how well CanXida Remove (Formula RMV) works to relieve Candida overgrowth symptoms compared to a placebo. We recruited 60 women, aged 18-50, who said they were experiencing Candida symptoms. They were randomly split into two groups: 30 took CanXida Remove (Formula RMV), and 30 took a placebo (a fake treatment). For 12 weeks, they followed a set dosage plan, and we asked them to fill out questionnaires at the beginning, at the 6-week mark, and at the end of the study.

2.1.1. The Importance of Blinding

This trial was blinded, but what does blinding mean in this context? Blinding in clinical trials means that participants and sometimes the researchers don’t know who is getting the real treatment and who is getting the placebo. This helps prevent bias and ensures more reliable results.

To ensure fair results that were free from bias, we performed triple blinding. This meant:

• The participants did not know whether they received CanXida Remove (Formula RMV) or the placebo.
• The researchers performing the trial were unaware of what they were giving to the participants.
• The CanXida team, including the scientists who analyzed the results, did not know who received what until the results were finalized.

3. Results

Before examining the results, it’s important to understand the term “statistical significance.” Statistical significance in clinical trials means that the results are unlikely to have happened by chance. Simply put, when a result is statistically significant, the finding is scientifically valid. Statistical significance is a tool that helps scientists separate real patterns from random chance. It’s a starting point for understanding results but not the whole story. When looking at scientific findings, it’s always important to ask not just “Is it significant?” but also “Is it meaningful?”²⁷

Another important point to remember is that the results sections of clinical trials (or any scientific study) only present the actual data and findings. They do not provide an interpretation of those findings (i.e., what the results mean). This is usually done in the discussion section.

3.1. Safety

The participants tolerated CanXida Remove (Formula RMV) well, and there were no dropouts due to tolerance issues.

3.2. Overall Digestive Wellbeing

At the end of the trial, there was a statistically significant improvement in how participants rated their “overall gastrointestinal health” after taking CanXida Remove (Formula RMV), while there was no significant difference in the placebo group.

3.3. Mental Well-Being

At the end of the trial, there was a statistically significant improvement in how participants rated their “mental well-being” after taking CanXida Remove (Formula RMV), while there was no significant difference in the placebo group.

3.4. Continued Use

At the end of the trial, the majority of participants agreed that they would “like to continue using this product”.

3.5. Recommend to Friends and Family

After six weeks, the majority of participants agreed that they would “recommend this product to their friends and family.”

4. Discussion and Future Directions

4.1. Gastrointestinal health and mental well-being

We were delighted to see that participants felt that their gastrointestinal and mental health improved while taking CanXida Remove (Formula RMV). The ingredients in this formulation have scientifically proven effects against a wide range of potential pathogens that can disrupt gut health and reduce feelings of digestive well-being. Based on these results, we believe that the depletion of different fungi, bacteria, and potentially parasites by CanXida Remove (Formula RMV) ingredients contributed to improved digestive well-being. However, further testing is required to confirm this.

The improvements in feelings of mental well-being could be due to improvements in feelings of gastrointestinal health or changes in the gut microbiome contributing to improved mental health, as has been proposed elsewhere²⁸. Relieving gastrointestinal symptoms can certainly help with mental well-being, especially in individuals who have suffered from symptoms for a long time.

Many of our clients’ testimonials support these results anecdotally. While testimonials are not the same as scientific data, they offer important information on the use cases for CanXida Remove (Formula RMV) and provide evidence for its effectiveness in individual cases.

4.2. Continued Use and Recommending to Friends and Family

The improvements in gastrointestinal and mental health were borne out in a majority of participants agreeing that they would like to continue using the product and that they would recommend it to family and friends. This is once again reflected in many client testimonials.

4.3. Future Directions

As stated at the beginning of this report, we performed this clinical trial to lay the foundation for future work. Getting everything right the first time isn’t easy, but every journey needs a first step. We have learned a lot from this study, including how trial length and recruitment procedures may affect the results. This puts us in a great position to design the next trials.

We want to thank our clients for their feedback and understanding as we strive to perfect our formulations. We are in the process of planning our next clinical trial and look forward to sharing the results with you soon.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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